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STEROID 21-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 21-Hydroxylase
Descriptor
Spanish
:
Esteroide 21-Hidroxilasa
Descriptor
Portuguese
:
Esteroide 21-Hidroxilase
Synonyms
English
:
21 Hydroxylase
21-Hydroxylase
Cytochrome P 450 21 Hydroxylase
Cytochrome P 450 CYP21
Cytochrome P 450 c21
Cytochrome P-450 21-Hydroxylase
Cytochrome P-450 CYP21
Cytochrome P-450 c21
Cytochrome P-450(c-21)
Cytochrome P450c21
P-450 c21, Cytochrome
Progesterone 21 Hydroxylase
Progesterone 21-Hydroxylase
Steroid 21 Hydroxylase
Steroid 21 Monooxygenase
Steroid 21-Monooxygenase
Steroid-21-Hydroxylase
Tree Number:
D08.244.453.493.500
D08.244.453.915.760
D08.811.682.690.708.170.463.500
D08.811.682.690.708.170.915.760
D12.776.422.220.453.493.500
D12.776.422.220.453.915.760
Definition
English
:
An adrenal microsomal
cytochrome
P450 enzyme that catalyzes the 21-hydroxylation of
steroids
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid
hormones
(
CORTICOSTERONE
;
HYDROCORTISONE
). Defects in CYP21 cause congenital adrenal
hyperplasia
(ADRENAL
HYPERPLASIA
, CONGENITAL).
Entry Combination - descr/qualif
English
:
Steroid 21-Hydroxylase
/
deficiency
use
Adrenal Hyperplasia, Congenital
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23465
Unique Identifier:
D013255
Occurrence in VHL
:
Similar:
DeCS